![]() Deleterious changes to insulin sensitivity and/or blood glucose levels throughout treatment with Trintellix might increase your hunger and cause weight gain. Though blood sugar changes aren’t known to be a common side effect, any medication that alters central serotonergic neurotransmission alter the hypothalamic-pituitary-adrenal axis, which in turn, affects insulin sensitivity. Blood sugar changes: Some individuals might experience blood sugar changes as a result of Trintellix. ![]() If you suspect bloating as a cause of your weight gain, realize that it’s probably not actual “fat gain,” rather, a bit of extra water retention. Bloating may be related to changes in gut bacteria and/or gastrointestinal distress as a result of Trintellix treatment. However, among those who notice weight gain from Trintellix, it’s possible that bloating (or water retention is the cause). Bloating: Most people won’t gain a significant amount of weight while using Trintellix.That said, even if you didn’t have a low appetite before Trintellix, there’s a chance that the medication could enhance your appetite – possibly causing weight gain. If your appetite normalizes (from a previously low appetite) while using Trintellix – you might consume more calories than you previously had been, and you may gain some weight. In the event that you had untreated depression and weren’t consuming much food because the depression interfered with your appetite, you might find that Trintellix alleviates your depression, which in turn, normalizes your appetite. Appetite increase: It is known that, for a subset of individuals, untreated depression results in low appetite which might lead to low caloric intake, weight loss, and a potentially an underweight BMI.Others might end up gaining weight because Trintellix slightly altered their hormones and/or metabolism. Certain individuals might end up gaining weight because Trintellix increased their appetite (or reversed their poor appetite stemming from untreated major depressive disorder). Understand that the specific causes of weight gain among Trintellix users (who end up gaining weight) will be subject to significant individual variation. If you experience weight gain as a result of Trintellix, below are some potential causes. Trintellix (Vortioxetine) & Weight Gain: Possible Causes However, some individuals are concerned with potential side effects of Trintellix, including body weight change (weight gain or weight loss). Through its unique serotonergic action, many users of Trintellix find that the drug alleviates depressive symptoms. More specifically, Trintellix inhibits the serotonin transporter (SERT) antagonizes 5-HT3 receptors agonizes 5-HT1A receptors and antagonizes 5-HT7 receptors. Trintellix is classified as a “serotonin modulator and stimulator” in that it functions as an inhibitor, antagonist, and agonist of various serotonin receptors. In 2013, Trintellix received FDA approval for the treatment of major depressive disorder in the United States. Trintellix (Vortioxetine hydrobromide), formerly sold under the name Brintellix, is an antidepressant that was jointly developed by the pharmaceutical companies Lundbeck and Takeda.
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